Nature Search

Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex

Repair of topoisomerase 1 (TOP1) DNA protein crosslinks (DPC) limits the efficacy of the TOP1 inhibitor irinotecan in cancer therapy. Here, the authors identify pevonedistat, NEDD8 inhibitor, as synergistic with irinotecan by blocking neddylation-activated ubiquitin/proteasomal degradation of TOP1-DPC.

Yilun Sun
Simone A. Baechler
Yves Pommier
ResearchOpen Access23 Jun 2023
Nature Communications

Volume: 14, P: 1-20
Transcriptome-wide association analyses reveal the impact of regulatory variants on rice panicle architecture and causal gene regulatory networks

Panicle architecture significantly determines rice grain yield. Here, the authors investigate the transcriptome of young panicles from 275 rice varieties and propose a method to identify causal genes for panicle traits and construct regulatory networks.

Luchang Ming
Debao Fu
Weibo Xie
ResearchOpen Access18 Nov 2023
Nature Communications

Volume: 14, P: 1-15
Metasurface-based broadband hologram with high tolerance to fabrication errors

Xiaohu Zhang
Jinjin Jin
Xiangang Luo
ResearchOpen Access28 Jan 2016
Scientific Reports

Volume: 6, P: 1-7
How growing up without siblings affects the adult brain and behaviour in the CHIMGEN cohort

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Jie Tang
Jing Zhang
Yue Wu
Research31 Mar 2025
Nature Human Behaviour

Volume: 9, P: 1005-1022
Distinct effects of early-stage and late-stage socioeconomic factors on brain and behavioral traits

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Qiang Xu
Su Lui
Yue Wu
Research24 Feb 2025
Nature Neuroscience

Volume: 28, P: 676-687
Generation and detection of orbital angular momentum via metasurface

Jinjin Jin
Jun Luo
Xiangang Luo
ResearchOpen Access07 Apr 2016
Scientific Reports

Volume: 6, P: 1-7
Cross-ancestry genome-wide association studies of brain imaging phenotypes

Cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in Chinese Han and white British participants identify autosomal and X-chromosomal associations in more diverse populations.

Jilian Fu
Quan Zhang
Yue Wu
Research29 May 2024
Nature Genetics

Volume: 56, P: 1110-1120
Offshore wave and wind energy development in the Southern Hemisphere will remain optimal between 20°E and 180°E by 2100

The high wave energy potential may decrease in the future, while that of offshore wind energy could increase, particularly under the high carbon dioxide emission scenarios, but the region between 40°S and 60°S and 20°E and 180°E will remain optimal, according to a multi-model analysis of climate projections.

Xiaohu Zhao
Guohe Huang
Bo Pang
ResearchOpen Access19 Jun 2025
Communications Earth & Environment

Volume: 6, P: 1-12
Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes

Genome-wide association meta-analyses in populations of East Asian and European ancestries identify variant–trait associations for 44 hippocampal traits and provide insight into the genetic architectures of hippocampal and subfield volumes.

Nana Liu
Longjiang Zhang
Yue Wu
Research19 Jun 2023
Nature Genetics

Volume: 55, P: 1126-1137
A deep learning system for myopia onset prediction and intervention effectiveness evaluation in children

Ziyi Qi
Tingyao Li
Xun Xu
ResearchOpen Access07 Aug 2024
npj Digital Medicine

Volume: 7, P: 1-10
Direct ring-strain loading for visible-light accelerated bioorthogonal ligation via diarylsydnone-dibenzo[b,f ][1,4,5]thiadiazepine photo-click reactions

Strained alkenes are valuable reagents for rapid and selective labeling of biomolecules but may undergo side-reactions. Here direct excitation of an azobenzene generates a strained nitrogen-nitrogen double bond in situ which reacts with a photochemically-generated nitrile imine, allowing the labeling of live cells with spatiotemporal control.

Jingshuo Gao
Qin Xiong
Zhipeng Yu
ResearchOpen Access04 Mar 2020
Communications Chemistry

Volume: 3, P: 1-10

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