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Showing 1–5 of 5 results
Advanced filters: Author: Xiaowen Lyu Clear advanced filters

  • Phenotypic changes in exhausted T cells are linked to chromatin remodeling. Here the authors show that pharmacological inhibition of the H3K4me1/2 demethylase LSD1 promotes the persistence and enhances the therapeutic activity of adoptively transferred T cells for cancer therapy.

    • Fengqi Qiu
    • Peishan Jiang
    • Wanqiang Sheng
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Here the authors show that differentiation of hESCs into pancreatic cells involves changes in CTCF loops by alteration of pioneer factor recruitment, histone modifications, and DNA methylation, leading to changes in enhancer-promoter interactions and gene expression.

    • Xiaowen Lyu
    • M. Jordan Rowley
    • Victor G. Corces
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • Introducing Microcket, a versatile toolkit for read alignment and interacting pair extraction from 3D genomics data (including Hi-C and Micro-C) with improved speed and sensitivity.

    • Yu Zhao
    • Mengqi Yang
    • Kun Sun
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-7

  • The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

    • Jesse M. Engreitz
    • Heather A. Lawson
    • Ella K. Samer
    Reviews
    Nature
    Volume: 633, P: 47-57