This study reveals the role of Parkin-dependent apoptosis in lipopolysaccharideinduced acute respiratory distress syndrome (ARDS). Polydatin, an herbal resveratrol-related glucoside, significantly activates Parkin-dependent mitophagy to protect against mitochondria-dependent apoptosis and lung injury. Thus, polydatin may be useful for the treatment of ARDS.
- Tao Li
- Youtan Liu
- Yunfeng Li