Chemotherapy of glioma is limited by delivering drugs across blood-brain barrier (BBB) to tumor sites in brain. Here, this group designs a neutrally-charged nanoprobe with γ-glutamyl moieties decorated on the surface that enabling the effective delivery of sonosensitizer and immune agonist R848 across BBB through adsorptive mediated transcytosis, thereby eliciting the anticancer effects.
- Bo Li
- Gengjia Chen
- Xintao Shuai
