3-Deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHPS) is a key enzyme in the shikimate pathway for the biosynthesis of aromatic compounds, however, its activity is inhibited by L-Phe and L-Tyr. Here, the authors report the D154N point mutation of yeast DAHPS, which retains the wild type enzyme activity but relieves the inhibition by L-Phe, thus increasing the production of downstream aromatic amino acid derivatives.
- Huayi Liu
- Qingjie Xiao
- Yunzi Luo
