Ilamycin E/F target the ClpC1P1P2 protease, disrupting mycobacterial protein homeostasis and causing cell death. ClpX mutation of ClpXP1P2 protease confer resistance to ilamycin E/F, highlighting Clp proteases as key vulnerability/resistance nodes.
- Yamin Gao
- Cuiting Fang
- Tianyu Zhang