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Enantioselective de novo construction of 3‑oxindoles via organocatalyzed formal [3 + 2] annulation from simple arylamines

The de novo construction of enantioenriched 3-hydroxyindolenines and 3-oxindoles from easily available starting materials is highly desired. Here, the authors demonstrate an enantioselectively intermolecular direct [3 + 2] annulation of aryl amine with 2,3-diketoesters to construct 3-hydroxyindolenines with a chiral tertiary alcohol.

Yong Wang
Yanyan Li
Xiuling Cui
ResearchOpen Access23 Jul 2024
Nature Communications

Volume: 15, P: 1-10
S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism

Resistance to ferroptosis in hepatocellular carcinoma remains to be understood. Here, the authors identify S100 calcium binding protein P (S100P) as a ferroptosis suppressor in HCC cells, which promotes lysosomal degradation of acetyl-CoA carboxylase alpha (ACC1) to downregulate lipid biosynthesis.

Min Yang
Weiwei Cui
Bo Chu
ResearchOpen Access08 Jan 2025
Nature Communications

Volume: 16, P: 1-19
A facultative plasminogen-independent thrombolytic enzyme from Sipunculus nudus

Many thrombolytic agents depend on plasminogen, leading to D-dimer accumulation. Here, Tang et al. report a plasminogen-independent thrombolytic enzyme that degrades blood clots and D-dimer without plasminogen.

Mingqing Tang
Guoxing Ma
Ruian Xu
ResearchOpen Access24 Apr 2025
Nature Communications

Volume: 16, P: 1-19
Translocation of vaginal microbiota is involved in impairment and protection of uterine health

Here, the authors present a comparative analyses on vaginal and uterine microbiota in 1223 samples derived from 655 women with chronic endometritis, which, combined with animal experiments, characterize the microbial translocation in the female reproductive tract and its role in modulating uterine health.

Jinfeng Wang
Zhanzhan Li
Fangqing Zhao
ResearchOpen Access07 Jul 2021
Nature Communications

Volume: 12, P: 1-15
Single-cell multi-omics sequencing of human spermatogenesis reveals a DNA demethylation event associated with male meiotic recombination

Huang, Li, An, Yang, Cui et al. perform a single-cell multi-omics analysis of human spermatogenesis and identify a DNA demethylation event upon meiosis initiation, which is associated with meiotic recombination.

Yaping Huang
Lin Li
Xiao-Yang Zhao
Research18 Sept 2023
Nature Cell Biology

Volume: 25, P: 1520-1534
cGAS suppresses hepatocellular carcinoma independent of its cGAMP synthase activity

Dapeng Ma
Min Yang
Lihui Han
Research09 Apr 2024
Cell Death & Differentiation

Volume: 31, P: 722-737

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Enantioselective de novo construction of 3‑oxindoles via organocatalyzed formal [3 + 2] annulation from simple arylamines

S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism

A facultative plasminogen-independent thrombolytic enzyme from Sipunculus nudus

Translocation of vaginal microbiota is involved in impairment and protection of uterine health

Single-cell multi-omics sequencing of human spermatogenesis reveals a DNA demethylation event associated with male meiotic recombination

cGAS suppresses hepatocellular carcinoma independent of its cGAMP synthase activity

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Enantioselective de novo construction of 3‑oxindoles via organocatalyzed formal [3 + 2] annulation from simple arylamines

S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism

A facultative plasminogen-independent thrombolytic enzyme from Sipunculus nudus

Translocation of vaginal microbiota is involved in impairment and protection of uterine health

Single-cell multi-omics sequencing of human spermatogenesis reveals a DNA demethylation event associated with male meiotic recombination

cGAS suppresses hepatocellular carcinoma independent of its cGAMP synthase activity

Search

Quick links