Fibroblastic reticular cells (FRCs) provide structural support and soluble factors necessary for proper lymph node organization and function. Turley and colleagues use scRNA-seq to identify a unique Gremlin1-expressing FRC subset that is found in T cell zones. Grem1+ FRCs support the survival of resident cDCs and are necessary to promote T cell immunity.
- Varun N. Kapoor
- Sören Müller
- Shannon J. Turley
