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Showing 1–5 of 5 results

Advanced filters: Author: Xiurong Cai Clear advanced filters

Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis

Clonal hematopoiesis is driven by the selective advantage of mutant hematopoietic stem cells. Here, authors discover that elevated mitochondrial activity is a targetable mechanism by which mutant hematopoietic stem cells gain a selective advantage.

Kira A. Young
Mohsen Hosseini
Jennifer J. Trowbridge
ResearchOpen Access16 Apr 2025
Nature Communications

Volume: 16, P: 1-15
Senescence-associated lineage-aberrant plasticity evokes T-cell-mediated tumor control

Cellular senescence plays a crucial role in cancer therapy, influencing how tumours respond to treatment. Here, the authors show that therapy-induced senescence in B-cell lymphoma leads to myeloid-like plasticity, enhancing T-cell recognition and improving patient outcomes.

Dimitri Belenki
Paulina Richter-Pechanska
Clemens A. Schmitt
ResearchOpen Access31 Mar 2025
Nature Communications

Volume: 16, P: 1-20
Clonal hematopoiesis in myeloid malignancies and solid tumors

Trowbridge and colleagues provide a comprehensive review of clonal hematopoiesis in diverse cancer settings, from myeloid malignancies to solid tumors, covering underlying molecular and cellular mechanisms and exploring therapy-related approaches.

Xiurong Cai
Robert L. Bowman
Jennifer J. Trowbridge
Reviews18 Jul 2025
Nature Cancer

Volume: 6, P: 1133-1144
Group-DIA: analyzing multiple data-independent acquisition mass spectrometry data files

Yuanyue Li
Chuan-Qi Zhong
Jiahuai Han
Correspondence05 Oct 2015
Nature Methods

Volume: 12, P: 1105-1106
Characterization of the chloroplast genome of Gleditsia species and comparative analysis

Feng Xiao
Yang Zhao
Xueyan Jian
ResearchOpen Access21 Feb 2024
Scientific Reports

Volume: 14, P: 1-10