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Showing 1–2 of 2 results
Advanced filters: Author: Xue-Jiao Jing Clear advanced filters

  • Endothelial dysfunction has been shown to occur in HFpEF and we know that statins can target endothelial dysfunction by inhibiting miR-133a. Here the authors show that statins improve diastolic dysfunction in HFpEF by increasing the levels of a circRNA which, in turns, binds to miR-133a modulating its downstream targets.

    • Bin Li
    • Wen-Wu Bai
    • Shuang-Xi Wang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Jie He and colleagues report exome sequencing of 113 tumor-normal pairs of esophageal squamous cell carcinoma. They highlight mutations in genes involved in cell cycle and apoptosis regulation, histone modifier genes and genes encoding members of the Hippo and Notch pathways.

    • Yi-Bo Gao
    • Zhao-Li Chen
    • Jie He
    Research
    Nature Genetics
    Volume: 46, P: 1097-1102