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Showing 1–2 of 2 results
Advanced filters: Author: Xuelai Fan Clear advanced filters

  • In this Technical Report, the authors describe a new methodology for rapid and flexible knockdown of specific proteins in vitro and in vivo—without the need for genetic modification of the target—using a small peptide construct that targets the protein of interest and marks it for chaperone-mediated autophagy.

    • Xuelai Fan
    • Wu Yang Jin
    • Yu Tian Wang
    Research
    Nature Neuroscience
    Volume: 17, P: 471-480

  • Jin et al develop and characterise a blood-brain barrier and plasma membrane-permeable α-synuclein knockdown peptide, Tat-βsyn-degron. In two mouse models of Parkinson’s disease, they show that Tat-βsyn-degron decreases α-synuclein aggregates and microglial activation as well as reducing neuronal damage and motor impairment. This study demonstrates the therapeutic potential of Tat-βsyn-degron in Parkinson’s disease treatment.

    • Jack Wuyang Jin
    • Xuelai Fan
    • Yu Tian Wang
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-15