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Critical role for a high-plasticity cell state in lung cancer

The high-plasticity cell state (HPCS) is a critical hub that enables reciprocal transitions between cancer cell states, and targeting the HPCS may suppress cancer progression and eradicate treatment resistance.

Jason E. Chan
Chun-Hao Pan
Tuomas Tammela
ResearchOpen Access21 Jan 2026
Nature

P: 1-11
Proportion and related factors of depression and anxiety for patients with pulmonary nodules in China: a outpatient-based cross-sectional study

Kangdi Cao
Zhuo Wang
Wei Hou
ResearchOpen Access31 Aug 2025
Scientific Reports

Volume: 15, P: 1-9
Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1

Zhuang et al. show that breast-cancer-secreted DKK1, while promoting bone metastases via canonical WNT signalling, inhibits lung metastasis by antagonizing non-canonical Wnt signalling to suppress recruitment of anti-tumour immune cells.

Xueqian Zhuang
Hao Zhang
Guohong Hu
Research11 Sept 2017
Nature Cell Biology

Volume: 19, P: 1274-1285
Publisher Correction: Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis

Xueqian Zhuang
Qing Wang
Tuomas Tammela
Amendments and Corrections22 May 2025
Nature

Volume: 642, P: E17
Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis

Studies using mouse models of lung adenocarcinoma identify an association between age, iron homeostasis and tumour initiation potential that involves NUPR1 and lipocalin-2.

Xueqian Zhuang
Qing Wang
Tuomas Tammela
Research04 Dec 2024
Nature

Volume: 637, P: 184-194
MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination

Cong et al. show that MTSS1 suppresses breast cancer initiation by promoting ubiquitin-mediated suppression of the NF-κB pathway. Loss of this regulatory mechanism promotes the activation and expansion of tumor-initiating cells.

Min Cong
Yuan Wang
Guohong Hu
Research20 Jan 2020
Nature Cancer

Volume: 1, P: 222-234
MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells

SMAD7 is a transcriptional target and a negative regulator of TGFβ signalling forming a negative feedback loop. Here the authors show that in cancer cells TGFβ activates the expression of microRNA-182 that suppresses SMAD7 protein, promoting TGFβ-mediated breast tumour invasion and bone metastasis.

Jingyi Yu
Rong Lei
Guohong Hu
ResearchOpen Access20 Dec 2016
Nature Communications

Volume: 7, P: 1-12
Exercise and immunometabolic regulation in cancer

Exercise is a powerful modifier of organismal, tissue and cellular metabolism. In their Review, Koelwyn et al. highlight how exercise-induced alterations in the tumour microenvironment can affect immunometabolic mechanisms and how these changes may contribute to the benefits of exercise on cancer initiation and progression.

Graeme J. Koelwyn
Xueqian Zhuang
Lee W. Jones
Reviews14 Sept 2020
Nature Metabolism

Volume: 2, P: 849-857
Active terahertz beam steering based on mechanical deformation of liquid crystal elastomer metasurface

Active terahertz beam steering based on mechanical deformation of the LCE metasurface tuned infrared pump

Xiaolin Zhuang
Wei Zhang
Weili Zhang
ResearchOpen Access04 Jan 2023
Light: Science & Applications

Volume: 12, P: 1-10
Kindlin-2 suppresses transcription factor GATA4 through interaction with SUV39H1 to attenuate hypertrophy

Lihua Qi
Xiaochun Chi
Hongquan Zhang
ResearchOpen Access26 Nov 2019
Cell Death & Disease

Volume: 10, P: 1-13
A CD44v⁺ subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity

Jing Hu
Gang Li
Guohong Hu
ResearchOpen Access16 Mar 2017
Cell Death & Disease

Volume: 8, P: e2679

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