Molecules that recapitulate the structure and prion-like activity of misfolded tau hold promise as more relevant models of pathological tau propagation. Now, the macrocyclization of short tau fragments affords proteomimetics that seed tau aggregation in cells and adopt a β-arch conformation resembling those found in filaments from patient-derived extracts.
- Isaac J. Angera
- Xueyong Xu
- Juan R. Del Valle
