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Charting brain morphology in international healthy and neurological populations

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Zhizheng Zhuo
Li Chai
Yaou Liu
Research29 Dec 2025
Nature Neuroscience

Volume: 29, P: 420-434
Benchmarking AI-powered docking methods from the perspective of virtual screening

Artificial intelligence (AI)-based docking and scoring methods demonstrate considerable potential for virtual drug screening. Gu et al. go further by assessing the structural rationality of AI-predicted complex conformations from various sources.

Shukai Gu
Chao Shen
Yu Kang
Research13 Feb 2025
Nature Machine Intelligence

Volume: 7, P: 509-520
Brain-restricted mTOR inhibition with binary pharmacology

The combination of the brain-permeable mTOR inhibitor RapaLink-1 and the brain-impermeable FKBP12 ligand RapaBlock enable brain-specific inhibition of mTOR.

Ziyang Zhang
Qiwen Fan
Kevan M. Shokat
ResearchOpen Access14 Sept 2022
Nature

Volume: 609, P: 822-828
Ultra-fast triplet-triplet-annihilation-mediated high-lying reverse intersystem crossing triggered by participation of nπ*-featured excited states

Here, the authors investigate naphthalimide-based compounds with cold triplet excitons utilized by triplet-triplet annihilation-mediated high-lying reverse intersystem crossing, and realize rate constant of over 10⁹ s⁻¹ with exciton utilization efficiency of 46.7% in organic light-emitting diodes.

Yanju Luo
Kai Zhang
Zhiyun Lu
ResearchOpen Access12 Nov 2022
Nature Communications

Volume: 13, P: 1-12
Development and validation of a basement membrane inflammatory response gene signature in lung adenocarcinoma

Shilei Liu
Fengchu Liao
Pengfei Zhang
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-18

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Charting brain morphology in international healthy and neurological populations

Benchmarking AI-powered docking methods from the perspective of virtual screening

Brain-restricted mTOR inhibition with binary pharmacology

Ultra-fast triplet-triplet-annihilation-mediated high-lying reverse intersystem crossing triggered by participation of nπ*-featured excited states

Development and validation of a basement membrane inflammatory response gene signature in lung adenocarcinoma

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