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Natural variation in SBRR1 shows high potential for sheath blight resistance breeding in rice

A genome-wide association study in rice identifies variation in SBRR1 associated with sheath blight resistance. Introducing the SBRR1-R allele into a commercial rice variety reduces yield loss under severe exposure to sheath blight disease.

Zhiming Feng
Peng Gao
Shimin Zuo
ResearchOpen Access30 Jul 2025
Nature Genetics

Volume: 57, P: 2004-2016
Targeting FOXM1 condensates reduces breast tumour growth and metastasis

The transcription factor FOXM1 forms functional condensates, the formation of which can be targeted with a specific peptide to suppress breast cancer growth and metastasis.

Feng Xie
Xiaoxue Zhou
Long Zhang
Research15 Jan 2025
Nature

Volume: 638, P: 1112-1121
In vivo delivery of transcription factors with multifunctional oligonucleotides

Clinical translation of transcription factor therapeutics is limited by delivery problems. Now, an oligonucleotide that can bind and deliver transcription factors with high in vivo efficiency and treat acetaminophen-induced liver injury is reported.

Kunwoo Lee
Mohammad Rafi
Niren Murthy
Research27 Apr 2015
Nature Materials

Volume: 14, P: 701-706
Breast cancer cell-derived extracellular vesicles promote CD8⁺ T cell exhaustion via TGF-β type II receptor signaling

Understanding the factors that hamper immune therapy in breast cancer may increase the range of patients who benefit. Here authors show that breast cancer cells produce and subsequently transfer active TGF-β type II receptors to CD8 + T cells to render them exhausted, thus paralyzing the anti-tumor immune response.

Feng Xie
Xiaoxue Zhou
Fangfang Zhou
ResearchOpen Access01 Aug 2022
Nature Communications

Volume: 13, P: 1-18
Unusual Inner-Salt Guaiazulene Alkaloids and bis-Sesquiterpene from the South China Sea Gorgonian Muriceides collaris

Pinglin Li
Xiaoling Liu
Guoqiang Li
ResearchOpen Access09 Aug 2017
Scientific Reports

Volume: 7, P: 1-9

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Natural variation in SBRR1 shows high potential for sheath blight resistance breeding in rice

Targeting FOXM1 condensates reduces breast tumour growth and metastasis

In vivo delivery of transcription factors with multifunctional oligonucleotides

Breast cancer cell-derived extracellular vesicles promote CD8⁺ T cell exhaustion via TGF-β type II receptor signaling

Unusual Inner-Salt Guaiazulene Alkaloids and bis-Sesquiterpene from the South China Sea Gorgonian Muriceides collaris

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Natural variation in SBRR1 shows high potential for sheath blight resistance breeding in rice

Targeting FOXM1 condensates reduces breast tumour growth and metastasis

In vivo delivery of transcription factors with multifunctional oligonucleotides

Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling

Unusual Inner-Salt Guaiazulene Alkaloids and bis-Sesquiterpene from the South China Sea Gorgonian Muriceides collaris

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Breast cancer cell-derived extracellular vesicles promote CD8⁺ T cell exhaustion via TGF-β type II receptor signaling