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Elucidation of the noncovalent interactions driving enzyme activity guides branching enzyme engineering for α-glucan modification

In this work, the authors decipher the noncovalent interactions of branching enzymes (BE) with polysaccharides that drive enzyme activity, and report mechanism-guided engineering avenues to promote further development of these industrially important BEs.

Zhiyou Zong
Xuewen Zhang
Yuanxia Sun
ResearchOpen Access09 Oct 2024
Nature Communications

Volume: 15, P: 1-12
Cell-type-dependent histone demethylase specificity promotes meiotic chromosome condensation in Arabidopsis

The meiocyte-specific histone reader MMD1 competes with the C-terminal domain of the histone demethylase JMJ16 for binding to its catalytic domain, expanding the substrate specificity of JMJ16 from H3K4 alone in somatic cells to both H3K4 and H3K9 in meiocytes.

Jun Wang
Chaoyi Yu
Yingxiang Wang
Research22 Jun 2020
Nature Plants

Volume: 6, P: 823-837
Author Correction: Cell-type-dependent histone demethylase specificity promotes meiotic chromosome condensation in Arabidopsis

Jun Wang
Chaoyi Yu
Yingxiang Wang
Amendments and Corrections28 Jul 2020
Nature Plants

Volume: 6, P: 1194
PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells

Members of the PRDI-BF1 and RIZ homology domain (PRDM) family have been involved in the regulation of several pathological conditions, including cancer. Here the authors show that PRDM1/BLIMP1 promotes immune evasion by regulating PD-L1 expression in hepatocellular carcinoma cells.

Qing Li
Liren Zhang
Xuehao Wang
ResearchOpen Access12 Dec 2022
Nature Communications

Volume: 13, P: 1-17
SCF^RMF mediates degradation of the meiosis-specific recombinase DMC1

In eukaryotes the recombinase DMC1 is required for meiotic recombination, but it remains unclear how DMC1 stability is regulated. Here the authors identify a SCF complex which mediates ubiquitination and proteasomal degradation of DMC1.

Wanyue Xu
Yue Yu
Yingxiang Wang
ResearchOpen Access19 Aug 2023
Nature Communications

Volume: 14, P: 1-17
Center-environment feature models for materials image segmentation based on machine learning

Yuexing Han
Ruiqi Li
Yi Liu
ResearchOpen Access28 Jul 2022
Scientific Reports

Volume: 12, P: 1-9
An easy gene assembling strategy for light-promoted transfection by combining host-guest interaction of cucurbit[7]uril and gold nanoparticles

Jianwei Du
Peng Zhang
Youxiang Wang
ResearchOpen Access20 Jul 2017
Scientific Reports

Volume: 7, P: 1-10
The association between subclass-specific IgG Fc N-glycosylation profiles and hypertension in the Uygur, Kazak, Kirgiz, and Tajik populations

JN Liu
M Dolikun
W Wang
Research05 Jun 2018
Journal of Human Hypertension

Volume: 32, P: 555-563
CNS gene transfer mediated by a novel controlled release system based on DNA complexes of degradable polycation PPE-EA: a comparison with polyethylenimine/DNA complexes

Y Li
J Wang
S Wang
Research18 Dec 2003
Gene Therapy

Volume: 11, P: 109-114
MAL2 reprograms lipid metabolism in intrahepatic cholangiocarcinoma via EGFR/SREBP-1 pathway based on single-cell RNA sequencing

Tian Huang
Hengsong Cao
Yongxiang Xia
ResearchOpen Access12 Jun 2024
Cell Death & Disease

Volume: 15, P: 1-18
Microbial communities and arsenic biogeochemistry at the outflow of an alkaline sulfide-rich hot spring

Zhou Jiang
Ping Li
Yanxin Wang
ResearchOpen Access29 Apr 2016
Scientific Reports

Volume: 6, P: 1-10
The association between gallstones and metabolic syndrome in urban Han Chinese: a longitudinal cohort study

Qian Zhu
Xiubin Sun
Yanxun Liu
ResearchOpen Access22 Jul 2016
Scientific Reports

Volume: 6, P: 1-9
Performance of genetic risk factors in prediction of trichloroethylene induced hypersensitivity syndrome

Yufei Dai
Ying Chen
Yuxin Zheng
ResearchOpen Access20 Jul 2015
Scientific Reports

Volume: 5, P: 1-8
CMV enhancer/human PDGF-β promoter for neuron-specific transgene expression

BH Liu
X Wang
S Wang
Research18 Dec 2003
Gene Therapy

Volume: 11, P: 52-60

Search

Elucidation of the noncovalent interactions driving enzyme activity guides branching enzyme engineering for α-glucan modification

Cell-type-dependent histone demethylase specificity promotes meiotic chromosome condensation in Arabidopsis

Author Correction: Cell-type-dependent histone demethylase specificity promotes meiotic chromosome condensation in Arabidopsis

PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells

SCF^RMF mediates degradation of the meiosis-specific recombinase DMC1

Center-environment feature models for materials image segmentation based on machine learning

An easy gene assembling strategy for light-promoted transfection by combining host-guest interaction of cucurbit[7]uril and gold nanoparticles

The association between subclass-specific IgG Fc N-glycosylation profiles and hypertension in the Uygur, Kazak, Kirgiz, and Tajik populations

CNS gene transfer mediated by a novel controlled release system based on DNA complexes of degradable polycation PPE-EA: a comparison with polyethylenimine/DNA complexes

MAL2 reprograms lipid metabolism in intrahepatic cholangiocarcinoma via EGFR/SREBP-1 pathway based on single-cell RNA sequencing

Microbial communities and arsenic biogeochemistry at the outflow of an alkaline sulfide-rich hot spring

The association between gallstones and metabolic syndrome in urban Han Chinese: a longitudinal cohort study

Performance of genetic risk factors in prediction of trichloroethylene induced hypersensitivity syndrome

CMV enhancer/human PDGF-β promoter for neuron-specific transgene expression

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