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Showing 1–3 of 3 results
Advanced filters: Author: Ya-Yuan Fu Clear advanced filters

  • The role of the immune system in tissue regeneration remains poorly understood. Here, in bone marrow transplantation and organoid culture models, T-cell-derived Interferon-γ is shown to promote STAT1-dependent intestinal stem cell c-MYC expression and epithelial regeneration.

    • Shuichiro Takashima
    • Roshan Sharma
    • Alan M. Hanash
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Innate lymphoid cells increase the growth of mouse intestinal organoids via IL-22 production; recombinant IL-22 promotes growth of both mouse and human organoids, and promotes mouse intestinal stem cell (ISC) expansion and ISC-driven organoid growth via a STAT3-dependent pathway and independently of Paneth cells; IL-22 treatment in vivo enhances the recovery of ISCs from intestinal injury.

    • Caroline A. Lindemans
    • Marco Calafiore
    • Alan M. Hanash
    Research
    Nature
    Volume: 528, P: 560-564