Neuroendocrine prostate cancer (NEPC) is an aggressive prostate cancer (PCa) variant. The exact mechanism underlying PCa development remains unclear due to the limited availability of NEPC models. In this review, the authors summarize strategies for NEPC model development and methods for model evaluation; discuss the origin of NEPC and the neuroendocrine transformation mechanism; and propose the challenges associated with research on NEPC. This study provides valuable insights into NEPC development and reveals potential therapeutic targets for NEPC.
- Xue Shui
- Rong Xu
- Changhong Shi
