This Review describes the current understanding of the molecular mechanism of inherited arrhythmias. Focus is placed on arrhythmia-causing mutations in the genes encoding the α subunit of the cardiac sodium channel (SCN5A) but arrhythmia-causing mutations in the genes encoding the β subunit and other proteins in the associated macromolecular complex are also discussed.
- Yanfei Ruan
- Nian Liu
- Silvia G. Priori
