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A cohort of mRNAs undergo high-stoichiometry NSUN6-mediated site-specific m⁵C modification

mRNA modifications like m⁵C are typically introduced by tRNA-modifying enzymes, while the catalytic mechanism and function remain debated. Here, the authors show that NSUN6 catalyzes tRNA and mRNA substrates in different ways, and that NSUN6 promotes breast cancer cell migration through mRNA m⁵C modification.

Yuan-Yuan Zhang
Cai-Tao Li
Ru-Juan Liu
ResearchOpen Access04 Jul 2025
Nature Communications

Volume: 16, P: 1-19
Engineering of human brain organoids with a functional vascular-like system

Expression of ETV2 in human cortical organoids induces the formation of vascular-like networks, which reduces cell death within organoids and increases their functional maturation.

Bilal Cakir
Yangfei Xiang
In-Hyun Park
Research07 Oct 2019
Nature Methods

Volume: 16, P: 1169-1175
Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids

The study of human microglia function in health and disease is limited by the availability of sound models. Here, the authors develop a method to generate functional microglia in human cortical organoids and investigate the role of human microglia during amyloid beta1-42- induced inflammation.

Bilal Cakir
Yoshiaki Tanaka
In-Hyun Park
ResearchOpen Access20 Jan 2022
Nature Communications

Volume: 13, P: 1-15
Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a

Uhrf1 is a known regulator of heterochromatin and DNA methylation in embryonic stem cells (ESCs). Here, the authors demonstrate that Uhrf1 acts together with the Set1/COMPASS complex regulator of active transcription to promote H3K4 methylation at bivalent loci and Uhrf1 loss results in disruption of differentiation.

Kun-Yong Kim
Yoshiaki Tanaka
In-Hyun Park
ResearchOpen Access03 Jul 2018
Nature Communications

Volume: 9, P: 1-13
Scalable production of tissue-like vascularized liver organoids from human PSCs

Sean P. Harrison
Richard Siller
Gareth J. Sullivan
ResearchOpen Access01 Sept 2023
Experimental & Molecular Medicine

Volume: 55, P: 2005-2024
Exploration of alcohol use disorder-associated brain miRNA–mRNA regulatory networks

Yolpanhchana Lim
Jennifer E. Beane-Ebel
Huiping Zhang
ResearchOpen Access02 Oct 2021
Translational Psychiatry

Volume: 11, P: 1-10

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A cohort of mRNAs undergo high-stoichiometry NSUN6-mediated site-specific m5C modification

Engineering of human brain organoids with a functional vascular-like system

Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids

Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a

Scalable production of tissue-like vascularized liver organoids from human PSCs

Exploration of alcohol use disorder-associated brain miRNA–mRNA regulatory networks

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A cohort of mRNAs undergo high-stoichiometry NSUN6-mediated site-specific m⁵C modification