Nature Search

DeepSeek-R1 incentivizes reasoning in LLMs through reinforcement learning

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Daya Guo
Dejian Yang
Zhen Zhang
ResearchOpen Access17 Sept 2025
Nature

Volume: 645, P: 633-638
Potent antitumour activity of a new class of tumour-specific killer cells

Si.-Yi Chen
An-Gang Yang
Xue F. Huang
Research02 Jan 1997
Nature

Volume: 385, P: 78-80
Dunhuang manuscript fragment reassembly based on patch-level handwriting style recognition

Yutong Zheng
Langtai Cheng
Xuelong Li
ResearchOpen Access10 Oct 2025
npj Heritage Science

Volume: 13, P: 1-11
Inactivation of HIV-1 chemokine co-receptor CXCR-4 by a novel intrakine strategy

Ji-Dai Chen
Xuefan Bai
Si-Yi Chen
Research01 Oct 1997
Nature Medicine

Volume: 3, P: 1110-1116
Light helicity detector based on 2D magnetic semiconductor CrI₃

Two-dimensional magnetic semiconductors hold promise for spin- and valleytronic applications. Here, the authors report the realization of light helicity detectors based on graphene/CrI₃ van der Waals heterostructures, exhibiting a photocurrent behaviour determined by the magnetic state of CrI₃.

Xing Cheng
Zhixuan Cheng
Lun Dai
ResearchOpen Access25 Nov 2021
Nature Communications

Volume: 12, P: 1-6
EMC2 promotes triple negative breast cancer growth by protecting FDFT1 from endoplasmic reticulum associated degradation to impair ferroptosis susceptibility

Xinrui Dong
Huijuan Dai
Wenjin Yin
ResearchOpen Access10 Sept 2025
Oncogene

Volume: 44, P: 3713-3728
Glecirasib in KRAS^G12C-mutated nonsmall-cell lung cancer: a phase 2b trial

In a single-arm phase 2b trial, glecirasib, an oral KRAS-G12C inhibitor, had an overall response rate of 47.9% in patients with locally advanced or metastatic KRAS^G12C-mutated nonsmall-cell lung cancer.

Yuankai Shi
Jian Fang
Zhiyue Rao
Research06 Jan 2025
Nature Medicine

Volume: 31, P: 894-900
Composite Hedges Nanopores codec system for rapid and portable DNA data readout with high INDEL-Correction

DNA is a promising medium for data storage but requires efficient sequencing methods for real-time data retrieval. Here, authors introduce Composite Hedges Nanopores (CHN), a nanopore-based codec scheme that improves sequencing efficiency and data accuracy, supporting real-time data retrieval.

Xuyang Zhao
Junyao Li
Yi Li
ResearchOpen Access30 Oct 2024
Nature Communications

Volume: 15, P: 1-12
Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia

Whole-genome sequencing of 175 Mongolians representing six tribes highlights population-specific genetic architecture and substantial gene flow among northern Eurasian populations, including derived alleles shared by Mongolians and Finns.

Haihua Bai
Xiaosen Guo
Ye Yin
Research05 Nov 2018
Nature Genetics

Volume: 50, P: 1696-1704
Membrane remodeling by FAM92A1 during brain development regulates neuronal morphology, synaptic function, and cognition

The conserved BAR domain protein FAM92A1 is known to induce membrane curvature. Here, the authors report the crystal structure of its BAR domain and perform an extensive characterization of the brain and behavior of FAM92A1 knockout mice.

Liang Wang
Ziyun Yang
Xiaobo Cen
ResearchOpen Access23 Jul 2024
Nature Communications

Volume: 15, P: 1-30
Excess PrP^C inhibits muscle cell differentiation via miRNA-enhanced liquid–liquid phase separation implicated in myopathy

The prion protein PrP^C is known to play a role in skeletal muscle development and physiology, including in myopathy. Here, the authors report that excess PrP^C binds microRNAs that enhance its aggregation, which inhibits autophagy in muscle cells.

Jing Tao
Yanping Zeng
Yi Liang
ResearchOpen Access08 Dec 2023
Nature Communications

Volume: 14, P: 1-22
A developmental landscape of 3D-cultured human pre-gastrulation embryos

A 3D culture system to model human embryonic development, together with single-cell transcriptome profiling, provides insights into the molecular developmental landscape during human post-implantation embryogenesis.

Lifeng Xiang
Yu Yin
Tianqing Li
Research12 Dec 2019
Nature

Volume: 577, P: 537-542
Correction: Dimethyl fumarate promotes the degradation of HNF1B and suppresses the progression of clear cell renal cell carcinoma

Yue Dai
Hongchen Li
Yanping Xu
Amendments and CorrectionsOpen Access19 May 2025
Cell Death & Disease

Volume: 16, P: 1-2
Tricortical iliac crest allograft with anterolateral single rod screw instrumentation in the treatment of thoracic and lumbar spinal tuberculosis

Yanping Zeng
Yong Fan
Zehua Zhang
ResearchOpen Access03 Aug 2020
Scientific Reports

Volume: 10, P: 1-8
Defective thymic output in WAS patients is associated with abnormal actin organization

Wenyan Li
Xiaoyu Sun
Chaohong Liu
ResearchOpen Access20 Sept 2017
Scientific Reports

Volume: 7, P: 1-8
Dimethyl fumarate promotes the degradation of HNF1B and suppresses the progression of clear cell renal cell carcinoma

Yue Dai
Hongchen Li
Yanping Xu
ResearchOpen Access06 Feb 2025
Cell Death & Disease

Volume: 16, P: 1-12
TET2 orchestrates YAP signaling to potentiate targetable vulnerability in hepatocellular carcinoma

Jing He
Mingen Lin
Yanping Xu
ResearchOpen Access05 Jun 2025
Cell Death & Disease

Volume: 16, P: 1-12
Oncometabolite fumarate facilitates PD-L1 expression and immune evasion in clear cell renal cell carcinoma

Yi Gao
Shiyin Fan
Lei Lv
ResearchOpen Access03 Jun 2025
Cell Death & Disease

Volume: 16, P: 1-13
Burdens and trends of age-related macular degeneration at global, regional, and national levels,1990–2021: findings from the 2021 global burden of disease study

Yanping Zhou
Wenchang Jia
Xiaopan Li
Research17 Feb 2025
Eye

Volume: 39, P: 1517-1525
Elucidating the contributions of multiple aldehyde/alcohol dehydrogenases to butanol and ethanol production in Clostridium acetobutylicum

Zongjie Dai
Hongjun Dong
Yin Li
ResearchOpen Access20 Jun 2016
Scientific Reports

Volume: 6, P: 1-9
CRISPR/Cas9-mediated mutagenesis of ClBG1 decreased seed size and promoted seed germination in watermelon

Yanping Wang
Jinfang Wang
Yong Xu
ResearchOpen Access01 Apr 2021
Horticulture Research

Volume: 8, P: 1-12
Matrix stiffness regulates nucleus pulposus cell glycolysis by MRTF-A-dependent mechanotransduction

Haoran Xu
Kang Wei
Jun Dai
ResearchOpen Access14 Feb 2025
Bone Research

Volume: 13, P: 1-14
TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential

Jing He
Mingen Lin
Lei Lv
ResearchOpen Access08 Aug 2023
Cell Discovery

Volume: 9, P: 1-15
Publisher Correction: TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential

Jing He
Mingen Lin
Lei Lv
Amendments and CorrectionsOpen Access21 Sept 2023
Cell Discovery

Volume: 9, P: 1
Genomic and transcriptomic analysis of the Asian honeybee Apis cerana provides novel insights into honeybee biology

Qingyun Diao
Liangxian Sun
Jie Wu
ResearchOpen Access16 Jan 2018
Scientific Reports

Volume: 8, P: 1-14
A quantitative cSMART assay for noninvasive prenatal screening of autosomal recessive nonsyndromic hearing loss caused by GJB2 and SLC26A4 mutations

Mingyu Han
Zhifeng Li
Pu Dai
Research25 May 2017
Genetics in Medicine

Volume: 19, P: 1309-1316
Novel missense mutations in MYO7A underlying postlingual high- or low-frequency non-syndromic hearing impairment in two large families from China

Yi Sun
Jing Chen
Huijun Yuan
Research09 Dec 2010
Journal of Human Genetics

Volume: 56, P: 64-70
D-mannose induces TFE3-dependent lysosomal degradation of EGFR and inhibits the progression of NSCLC

Xue Sun
Yue Dai
Lei Lv
Research16 Oct 2023
Oncogene

Volume: 42, P: 3503-3513
Author Correction: Anomalous in-plane anisotropic Raman response of monoclinic semimetal 1 T′-MoTe₂

Qingjun Song
Haifeng Wang
Lun Dai
Amendments and CorrectionsOpen Access15 Dec 2017
Scientific Reports

Volume: 7, P: 1
Characteristics and adverse outcomes of Chinese adolescent pregnancies between 2012 and 2019

Yanxia Xie
Xiaodong Wang
Juan Liang
ResearchOpen Access15 Jun 2021
Scientific Reports

Volume: 11, P: 1-12
Provincial-level outcomes of China’s ‘Reducing maternal mortality and eliminating neonatal tetanus’ program

Peiran Chen
Mingrong Li
Hanming Liu
ResearchOpen Access07 Aug 2020
Scientific Reports

Volume: 10, P: 1-9
Preliminary Characterization and In Vivo Studies of Structurally Identical ¹⁸F- and ¹²⁵I-Labeled Benzyloxybenzenes for PET/SPECT Imaging of β-Amyloid Plaques

Yanping Yang
Xiaoyang Zhang
Boli Liu
ResearchOpen Access14 Jul 2015
Scientific Reports

Volume: 5, P: 1-11
Anomalous in-plane anisotropic Raman response of monoclinic semimetal 1 T´-MoTe₂

Qingjun Song
Haifeng Wang
Lun Dai
ResearchOpen Access11 May 2017
Scientific Reports

Volume: 7, P: 1-10
The prognostic value of the MASS in a multi-center cohort of patients with newly diagnosed multiple myeloma

Peiyu Yang
Fan Zhou
Fengyan Jin
CorrespondenceOpen Access14 Sept 2022
Blood Cancer Journal

Volume: 12, P: 1-4

Search

DeepSeek-R1 incentivizes reasoning in LLMs through reinforcement learning

Potent antitumour activity of a new class of tumour-specific killer cells

Dunhuang manuscript fragment reassembly based on patch-level handwriting style recognition

Inactivation of HIV-1 chemokine co-receptor CXCR-4 by a novel intrakine strategy

Light helicity detector based on 2D magnetic semiconductor CrI₃

EMC2 promotes triple negative breast cancer growth by protecting FDFT1 from endoplasmic reticulum associated degradation to impair ferroptosis susceptibility

Glecirasib in KRAS^G12C-mutated nonsmall-cell lung cancer: a phase 2b trial

Composite Hedges Nanopores codec system for rapid and portable DNA data readout with high INDEL-Correction

Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia

Membrane remodeling by FAM92A1 during brain development regulates neuronal morphology, synaptic function, and cognition

Excess PrP^C inhibits muscle cell differentiation via miRNA-enhanced liquid–liquid phase separation implicated in myopathy

A developmental landscape of 3D-cultured human pre-gastrulation embryos

Correction: Dimethyl fumarate promotes the degradation of HNF1B and suppresses the progression of clear cell renal cell carcinoma

Tricortical iliac crest allograft with anterolateral single rod screw instrumentation in the treatment of thoracic and lumbar spinal tuberculosis

Defective thymic output in WAS patients is associated with abnormal actin organization

Dimethyl fumarate promotes the degradation of HNF1B and suppresses the progression of clear cell renal cell carcinoma

TET2 orchestrates YAP signaling to potentiate targetable vulnerability in hepatocellular carcinoma

Oncometabolite fumarate facilitates PD-L1 expression and immune evasion in clear cell renal cell carcinoma

Burdens and trends of age-related macular degeneration at global, regional, and national levels,1990–2021: findings from the 2021 global burden of disease study

Elucidating the contributions of multiple aldehyde/alcohol dehydrogenases to butanol and ethanol production in Clostridium acetobutylicum

CRISPR/Cas9-mediated mutagenesis of ClBG1 decreased seed size and promoted seed germination in watermelon

Matrix stiffness regulates nucleus pulposus cell glycolysis by MRTF-A-dependent mechanotransduction

TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential

Publisher Correction: TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential

Genomic and transcriptomic analysis of the Asian honeybee Apis cerana provides novel insights into honeybee biology

A quantitative cSMART assay for noninvasive prenatal screening of autosomal recessive nonsyndromic hearing loss caused by GJB2 and SLC26A4 mutations

Novel missense mutations in MYO7A underlying postlingual high- or low-frequency non-syndromic hearing impairment in two large families from China

D-mannose induces TFE3-dependent lysosomal degradation of EGFR and inhibits the progression of NSCLC

Author Correction: Anomalous in-plane anisotropic Raman response of monoclinic semimetal 1 T′-MoTe₂

Characteristics and adverse outcomes of Chinese adolescent pregnancies between 2012 and 2019

Provincial-level outcomes of China’s ‘Reducing maternal mortality and eliminating neonatal tetanus’ program

Preliminary Characterization and In Vivo Studies of Structurally Identical ¹⁸F- and ¹²⁵I-Labeled Benzyloxybenzenes for PET/SPECT Imaging of β-Amyloid Plaques

Anomalous in-plane anisotropic Raman response of monoclinic semimetal 1 T´-MoTe₂

The prognostic value of the MASS in a multi-center cohort of patients with newly diagnosed multiple myeloma

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