Nature Search

HBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription

The regulatory mechanism and functional consequence of lysine lactylation remain to be explored. Here, the authors identify HBO1 as a lysine lactyltransferase and suggest a potential role of HBO1 in tumorigenesis through H3K9la-mediated transcription regulation.

Ziping Niu
Chen Chen
Kai Zhang
ResearchOpen Access26 Apr 2024
Nature Communications

Volume: 15, P: 1-15
The homeobox transcription factor DUXBL controls exit from totipotency

The transcription factor double homeobox protein (DUX) induces a totipotency-specific regulatory program, including the upregulation of DUXBL. DUXBL subsequently accesses DUX-bound regions and interacts with TRIM24 and TRIM33, thus contributing to totipotency exit.

Maria Vega-Sendino
Felipe F. Lüttmann
Sergio Ruiz
Research20 Mar 2024
Nature Genetics

Volume: 56, P: 697-709
MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme

Mitochondria maintain a balance between thermogenesis and ATP synthesis, but how this is coordinated is largely unknown. Here, the authors show that MFSD7C coordinates ATP synthesis and thermogenesis in response to heme by directly binding to electron transport chain complexes and SERCA2b.

Yingzhong Li
Nikola A. Ivica
Jianzhu Chen
ResearchOpen Access24 Sept 2020
Nature Communications

Volume: 11, P: 1-14
Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2

Oct4, along with Sox2 and Klf4 can induce pluripotency, but structurally similar factors like Oct6 cannot. Here, using pluripotency competent and incompetent factors, the authors show that Sox2 plays a dominant role in facilitating chromatin opening at Oct4 bound DNA early during reprogramming to pluripotency.

Vikas Malik
Laura V. Glaser
Ralf Jauch
ResearchOpen Access02 Aug 2019
Nature Communications

Volume: 10, P: 1-16
Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems

The side effects of cancer drugs limit their utility. Here, the authors developed a method in which an inactive (prodrug) version of the cancer drug doxorubicin enters tumour cells and then gets activated inside the cells upon a trigger facilitated by enzyme-instructed supramolecular self-assembly.

Qingxin Yao
Feng Lin
Yuan Gao
ResearchOpen Access28 Nov 2018
Nature Communications

Volume: 9, P: 1-9
Scientists and teachers should ignore politics

Minna J. Hsu
Govindasamy Agoramoorthy
Correspondence06 Oct 2004
Nature

Volume: 431, P: 627
Large area MoS₂ thin film growth by direct sulfurization

Kai-Yao Yang
Hong-Thai Nguyen
Hsiang-Chen Wang
ResearchOpen Access24 May 2023
Scientific Reports

Volume: 13, P: 1-9
Validation of bifurcation DEFINITION criteria and comparison of stenting strategies in true left main bifurcation lesions

Juan Wang
Changdong Guan
Bo Xu
ResearchOpen Access26 Jun 2020
Scientific Reports

Volume: 10, P: 1-12
Transfer learning with CNNs for efficient prostate cancer and BPH detection in transrectal ultrasound images

Te-Li Huang
Nan-Han Lu
Tai-Been Chen
ResearchOpen Access09 Dec 2023
Scientific Reports

Volume: 13, P: 1-9
Assessment of hyperspectral imaging and CycleGAN-simulated narrowband techniques to detect early esophageal cancer

Kai-Yao Yang
Arvind Mukundan
Hsiang-Chen Wang
ResearchOpen Access22 Nov 2023
Scientific Reports

Volume: 13, P: 1-10
The application of machine learning techniques in posttraumatic stress disorder: a systematic review and meta-analysis

Jing Wang
Hui Ouyang
Weizhi Liu
ReviewsOpen Access09 May 2024
npj Digital Medicine

Volume: 7, P: 1-13

Search

Filter By:

Search

Quick links