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Showing 1–5 of 5 results
Advanced filters: Author: Yanxin Pei Clear advanced filters

  • Phosphoribosyl pyrophosphate synthetase (PRPS1), an enzyme that regulates de novo nucleotide synthesis, was found to be O-GlcNAcylated, which increases PRPS1 activity, and is associated with increased tumorigenesis and resistance to chemoradiotherapy.

    • Lulu Chen
    • Qi Zhou
    • Huadong Pei
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 20, P: 19-29

  • FCH domain only 1 (FCHO1) is a key molecule involved in clathrin-mediated endocytosis (CME). Here, the authors report homozygous FCHO1 mutations in individuals with variable T and B cell lymphopenia, which are associated with loss-of-function of FCHO1 and impaired formation of clathrin-coated pits in T cells.

    • Marcin Łyszkiewicz
    • Natalia Ziętara
    • Christoph Klein
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Medulloblastomas are the most common malignant childhood brain tumours and are thought to arise from the cerebellum. There is substantial heterogeneity among medulloblastomas and some are thought to arise following aberrant Sonic Hedgehog pathway activation. It is now shown that a distinct subtype of medulloblastoma arises from the dorsal brainstem and is associated with altered WNT signalling. Distinct molecular and clinical profiles of the subtypes have implications for future treatment.

    • Paul Gibson
    • Yiai Tong
    • Richard J. Gilbertson
    Research
    Nature
    Volume: 468, P: 1095-1099