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Showing 1–6 of 6 results
Advanced filters: Author: Yared Hailemichael Clear advanced filters

  • Using an adapted competitive peptide phage display platform, Hong Qin and colleagues identify new candidate peptides specifically binding myeloid-derived suppressor cells (MDSCs), with which they generate peptide-Fc fusion proteins (peptibodies). The peptibodies deplete intra-umoral MDSCs in several mouse tumor models, in addition to those in blood and spleen, with limited off-target activity and superiority over standard depletion methods. Validation of this approach for cell type–specific surface marker discovery identified S100A9 as a target on the surface of MDSCs.

    • Hong Qin
    • Beatrisa Lerman
    • Larry W Kwak
    Research
    Nature Medicine
    Volume: 20, P: 676-681

  • Interleukin-2 can induce an anti-tumour response, but is associated with toxicity. Here, the authors demonstrate that an engineered interleukin-2 promotes intratumoral T regulatory cell depletion while enhancing effective anti-tumour CD8+ T cell responses that result in potent tumor suppression.

    • Meenu Sharma
    • Hiep Khong
    • Willem W. Overwijk
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Cancer vaccines have had limited success in eliminating tumors in patients. Here Willem Overwijk and colleagues report that one reason for the failure of peptide-based vaccines may be their formulation. Their research shows that peptides formulated in incomplete Freund's adjuvant sequester CD8+ T cells at the site of injection, leading to T cell dysfunction and eventual apoptosis. A peptide and adjuvant formulation that did not persist long term at the injection site showed superior ability to induce a functional antitumor T cell response.

    • Yared Hailemichael
    • Zhimin Dai
    • Willem W Overwijk
    Research
    Nature Medicine
    Volume: 19, P: 465-472

  • Treatment options for metastatic melanoma are limited. Here the authors show that combining an immunostimulant adenovirus, currently in clinical trials for leukemia, with immune checkpoints blockade (ICB) results in systemic eradication of ICB resistant melanoma tumours from both skin and brain of mice.

    • Manisha Singh
    • Christina Vianden
    • Willem W. Overwijk
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • Grail is an E3 ubiquitin ligase that inhibits T-cell receptor signalling in CD4+ T cells. Here the authors show Grail also limits IL-21 receptor expression and function in CD8+ T cells, is overactive in these cells in patients with lymphoma, and promotes tumour development in a lymphoma transplant mouse model.

    • Cara Haymaker
    • Yi Yang
    • Roza Nurieva
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14