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Showing 1–3 of 3 results
Advanced filters: Author: Yasaman Aghazadeh Clear advanced filters

  • “Here the authors demonstrate that ß cell differentiation from human pluripotent stem cells can be improved by replacing nicotinamide with tankyrase inhibitors. This results in pancreatic progenitors that form islet-like cells with increased ß cell frequencies and glucose responsiveness.”

    • Frankie Poon
    • Rangarajan Sambathkumar
    • M. Cristina Nostro
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Pancreatic progenitors (PPs) can be derived from human pluripotent stem cells in vitro but efficiency of differentiation varies, making it hard to sort for insulin-producing cells. Here, the authors use a proteomic approach to identify the secretory granule membrane glycoprotein 2 as a marker for PDX1+/NKX6-1+ PPs.

    • Kathryn F. Cogger
    • Ankit Sinha
    • M. Cristina Nostro
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13