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Advanced filters: Author: Yasmine Neirijnck Clear advanced filters

  • Gonadal fate in mammals is determined during embryogenesis and is actively maintained in adulthood. This study shows that E3-SUMO ligase activity of TRIM28 is required for ovarian identity maintenance and testicular-specific gene repression in mouse adult ovary; in its absence, ovarian granulosa cells transdifferentiate to Sertoli cells.

    • Moïra Rossitto
    • Stephanie Déjardin
    • Francis Poulat
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19