Nature Search

Sequence and expression of transcripts of the human T-cell receptor β- chain genes

Yasunobu Yoshikai
Demetri Anatoniou
Tak. W. Mak
Research06 Dec 1984
Nature

Volume: 312, P: 521-524
Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer

Pamela S. Ohashi
Tak W. Mak
Arthur Weiss
Research01 Aug 1985
Nature

Volume: 316, P: 606-609
Athymic mice express a high level of functional γ-chain but greatly reduced levels of α- and β-chain T-cell receptor messages

Yasunobu Yoshikai
Marciano D. Reis
Tak W. Mak
Research04 Dec 1986
Nature

Volume: 324, P: 482-485
Presence of T-cell receptor mRNA in functionally distinct T cells and elevation during intrathymic differentiation

Yasunobu Yoshikai
Yusuke Yanagi
Tak W. Mak
Research09 Aug 1984
Nature

Volume: 310, P: 506-508
A chromosome 14 inversion in a T-cell lymphoma is caused by site-specific recombination between immunoglobulin and T-cell receptor loci

Christopher T. Denny
Yasunobu Yoshikai
Ilan R. Kirsch
Research10 Apr 1986
Nature

Volume: 320, P: 549-551
A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

Yusuke Yanagi
Yasunobu Yoshikai
Tak W. Mak
Research08 Mar 1984
Nature

Volume: 308, P: 145-149
Organization and sequences of the variable, joining and constant region genes of the human T-cell receptor α-chain

Yasunobu Yoshikai
Stephen P. Clark
Tak W. Mak
Research29 Aug 1985
Nature

Volume: 316, P: 837-840
Identification of a diversity segment of human T-cell receptor β-chain, and comparison with the analogous murine element

Stephen P. Clark
Yasunobu Yoshikai
Tak W. Mak
Research27 Sept 1984
Nature

Volume: 311, P: 387-389
TYK2 signaling promotes the development of autoreactive CD8⁺ cytotoxic T lymphocytes and type 1 diabetes

TYK2 is a candidate susceptibility gene for type 1 diabetes (T1D) and a beneficial effect has been reported for TYK2 inhibitors for other autoimmune diseases. In this study, the authors generate Tyk2 KO mice on a NOD background and demonstrate that TYK2 signaling drives CD8⁺ T cell autoreactivity and T1D.

Keiichiro Mine
Seiho Nagafuchi
Keizo Anzai
ResearchOpen Access13 Feb 2024
Nature Communications

Volume: 15, P: 1-14
Dectin-1 signaling on colonic γδ T cells promotes psychosocial stress responses

Kamiya and colleagues examine the effects of chronic social-defeat stress on the intestinal microbiome and show a pathological role played by dectin-1 and interleukin-17 expressed by gut γδ T cells on this behavioral vulnerability.

Xiaolei Zhu
Shinji Sakamoto
Atsushi Kamiya
Research20 Mar 2023
Nature Immunology

Volume: 24, P: 625-636
IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2⁺Vγ6⁺γδ T cells

Control of γδ T-cell activation remains incompletely understood. Here the authors show that during autoimmune arthritis development αβ CD4⁺T cells recruit a subset of IL-17-producing γδ T cells to the joints, and that both components are essential to cause pathology in a mouse model of the disease.

Aoi Akitsu
Harumichi Ishigame
Yoichiro Iwakura
ResearchOpen Access25 Jun 2015
Nature Communications

Volume: 6, P: 1-15
Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes

Diabetes can be caused by viral infections in humans and some inbred mice, suggesting genetic predisposition. Here the authors show that mutations in Tyk2 gene underlie susceptibility to virus-induced diabetes in mice, due to Tyk2requirement for antiviral response in insulin-producing cells.

Kenichi Izumi
Keiichiro Mine
Seiho Nagafuchi
ResearchOpen Access07 Apr 2015
Nature Communications

Volume: 6, P: 1-10
IL-21/IL-21R signaling suppresses intestinal inflammation induced by DSS through regulation of Th responses in lamina propria in mice

Yuanyuan Wang
Xuefeng Jiang
Yasunobu Yoshikai
ResearchOpen Access22 Aug 2016
Scientific Reports

Volume: 6, P: 1-14

Search

Sequence and expression of transcripts of the human T-cell receptor β- chain genes

Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer

Athymic mice express a high level of functional γ-chain but greatly reduced levels of α- and β-chain T-cell receptor messages

Presence of T-cell receptor mRNA in functionally distinct T cells and elevation during intrathymic differentiation

A chromosome 14 inversion in a T-cell lymphoma is caused by site-specific recombination between immunoglobulin and T-cell receptor loci

A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

Organization and sequences of the variable, joining and constant region genes of the human T-cell receptor α-chain

Identification of a diversity segment of human T-cell receptor β-chain, and comparison with the analogous murine element

TYK2 signaling promotes the development of autoreactive CD8⁺ cytotoxic T lymphocytes and type 1 diabetes

Dectin-1 signaling on colonic γδ T cells promotes psychosocial stress responses

IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2⁺Vγ6⁺γδ T cells

Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes

IL-21/IL-21R signaling suppresses intestinal inflammation induced by DSS through regulation of Th responses in lamina propria in mice

Search

Quick links

Search

Filter By:

Search

Quick links