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Showing 1–9 of 9 results

Advanced filters: Author: Yate-Ching Yuan Clear advanced filters

A novel DNA-binding motif shares structural homology to DNA replication and repair nucleases and polymerases

Yate-Ching Yuan
Robert H. Whitson
Yuan Chen
Research01 Nov 1998
Nature Structural Biology

Volume: 5, P: 959-964
High-resolution characterization of gene function using single-cell CRISPR tiling screen

Identifying functional domains and genetic regulatory mechanisms is essential for developing new therapies. Here the authors present sc-Tiling, single-cell high-density CRISPR tiling screening for functional domain characterization.

Lu Yang
Anthony K. N. Chan
Chun-Wei Chen
ResearchOpen Access01 Jul 2021
Nature Communications

Volume: 12, P: 1-9
Nelfinavir and Nelfinavir Analogs Block Site-2 Protease Cleavage to Inhibit Castration-Resistant Prostate Cancer

Min Guan
Leila Su
Warren A. Chow
ResearchOpen Access16 Apr 2015
Scientific Reports

Volume: 5, P: 1-8
Gene expression associated with endocrine therapy resistance in estrogen receptor-positive breast cancer

Veronica Jones
Hongwei Holly Yin
Victoria Seewaldt
ResearchOpen Access28 Feb 2025
Scientific Reports

Volume: 15, P: 1-14
Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia

In chronic myelogenous leukemia, leukemia stem cell function requires a microRNA that is provided by bone marrow endothelial cells.

Bin Zhang
Le Xuan Truong Nguyen
Guido Marcucci
Research05 Mar 2018
Nature Medicine

Volume: 24, P: 450-462
A germline missense mutation in COQ6 is associated with susceptibility to familial schwannomatosis

Keqiang Zhang
Jia-Wei Lin
Yun Yen
ResearchOpen Access24 Apr 2014
Genetics in Medicine

Volume: 16, P: 787-792
A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium

The Sequencing Quality Control (SEQC) consortium shows that junction discovery and differential gene expression profiling with RNA-seq can be robust but transcript-level and absolute measurements remain challenging.

Zhenqiang Su
Paweł P Łabaj
Leming Shi
Research24 Aug 2014
Nature Biotechnology

Volume: 32, P: 903-914
Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia

Studies employing serial bone marrow transplantation in mice show that Sirt1 knockout improves quiescence maintenance and function of aging hematopoietic stem cells. Sirt1 loss also prevents the development of age-dependent B/myeloid mixed phenotype acute leukemia.

Zhiqiang Wang
Chunxiao Zhang
WenYong Chen
ResearchOpen Access28 Apr 2022
Communications Biology

Volume: 5, P: 1-15
CF33-hNIS-antiPDL1 virus primes pancreatic ductal adenocarcinoma for enhanced anti-PD-L1 therapy

Zhifang Zhang
Annie Yang
Yanghee Woo
Research09 Jun 2021
Cancer Gene Therapy

Volume: 29, P: 722-733