Vaccination is often inferior to nature infection for the induction of lasting immunity. Here the authors combine masked TLR7/8 agonist with controlled release of antigens in a kinetically engineered vaccine (KE-VAC) to mimic immune responses during natural infection, and find KE-VAC inducing protective immunity for influenza, SARS-CoV-2 and SFTSV.
- Sang Nam Lee
- Young-Il Kim
- Yong Taik Lim