Schrecker, Son and colleagues identify the accessory subunits transmembrane protein 9 (TMEM9) and TMEM9B for chloride transporters ClC-3, ClC-4 and ClC-5 and establish the roles of TMEM9 and phosphatidylinositol 3,5-bisphosphate in the regulation of ClC-3 activity and endosomal ion homeostasis.
- Marina Schrecker
- Yeeun Son
- Richard K. Hite