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Signal Transduction and Targeted Therapy (1)
Nature Biomedical Engineering (1)

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Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells

Orthogonally conjugating the cytokine interleukin-2 to poly(ethylene glycol) moieties at defined protein sites improves its pharmacokinetics and half-life as well as its therapeutic performance in mouse models of autoimmune diseases.

Bo Zhang
Jiaqi Sun
Xuan Zhang
Research27 Sept 2021
Nature Biomedical Engineering

Volume: 5, P: 1288-1305
Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity

Bo Zhang
Jiaqi Sun
Xuan Zhang
ResearchOpen Access23 Jan 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-18

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Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells

Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity

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