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Showing 1–13 of 13 results
Advanced filters: Author: Yi-Mi Wu Clear advanced filters

  • The genetic factors involved in disease progression and drug resistance in multiple myeloma (MM) are varied and complex. Here, genomic and transcriptomic profiling of 511 relapsed and refractory MM patients reveals genetic alterations in several oncogenic pathways contributing to progression and resistance to MM therapies.

    • Josh N. Vo
    • Yi-Mi Wu
    • Arul M. Chinnaiyan
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Clinical exome and transcriptome sequencing of 500 adult patients with metastatic solid tumours of diverse lineage and biopsy site, as part of the Michigan Oncology Sequencing (MI-ONCOSEQ) Program.

    • Dan R. Robinson
    • Yi-Mi Wu
    • Arul M. Chinnaiyan
    Research
    Nature
    Volume: 548, P: 297-303

  • Exome sequencing is used to investigate the role of mutations and copy number aberrations in metastatic castration-resistant prostate cancer, revealing recurrent mutations in multiple chromatin/histone modifying genes, as well as genes involved in androgen signalling.

    • Catherine S. Grasso
    • Yi-Mi Wu
    • Scott A. Tomlins
    Research
    Nature
    Volume: 487, P: 239-243

  • This report identifies oncogenic fusions in individuals with breast cancer involving the genes encoding NOTCH and MAST, recurring in approximately 5–7% of studied cases. The fusions show growth-promoting properties that suggest that they may represent targetable events in a subset of people with breast cancer.

    • Dan R Robinson
    • Shanker Kalyana-Sundaram
    • Arul M Chinnaiyan
    Research
    Nature Medicine
    Volume: 17, P: 1646-1651

  • Arul Chinnaiyan and colleagues report the results of prospective clinical sequencing of 11 estrogen receptor–positive metastatic breast cancers. They identify ESR1 mutations affecting the ligand-binding domain in six hormone-resistant metastatic breast cancers and show that the mutant estrogen receptors are constitutively active and continue to be responsive to anti-estrogen therapies in vitro.

    • Dan R Robinson
    • Yi-Mi Wu
    • Arul M Chinnaiyan
    Research
    Nature Genetics
    Volume: 45, P: 1446-1451

  • Small-molecule compounds that target the BET domain in proteins such as BRD4 have recently been identified as potential anticancer agents; here, the efficacy of the BRD4-targeting compound JQ1 is demonstrated in castration-resistant prostate cancer driven by deregulated androgen receptor action.

    • Irfan A. Asangani
    • Vijaya L. Dommeti
    • Arul M. Chinnaiyan
    Research
    Nature
    Volume: 510, P: 278-282

  • Arul Chinnaiyan and colleagues report the curation of 7,256 RNA sequencing libraries from tumors, normal tissues and cell lines. They find 58,648 lncRNAs, of which 79% are previously unnannotated.

    • Matthew K Iyer
    • Yashar S Niknafs
    • Arul M Chinnaiyan
    Research
    Nature Genetics
    Volume: 47, P: 199-208