The authors show that mice lacking one copy of gene encoding the transcription factor T-box brain 1 (TBR1) show deficient axonal projections from amygdala neurons, as well as social and cognitive behavioral deficits. Tbr1 haploinsufficiency alters expression of multiple Tbr1 target genes, and restoring their expression restores axon outgrowth defects in vivo.
- Tzyy-Nan Huang
- Hsiu-Chun Chuang
- Yi-Ping Hsueh
