Bicyclo[2.1.1]hexanes (BCHs), three-dimensional benzene bioisosteres characterized by high sp3-carbon content, hold great promise for diverse applications in medicinal chemistry. Here, authors report a secondary amine–catalyzed asymmetric [2π + 2σ] cycloaddition of bicyclo[1.1.0]butanes (BCBs) with α,β-unsaturated aldehydes.
- Yi-Xiang Geng
- Teng-Fei Xiao
- Peng-Fei Xu
