Nature Search

STIM1-mediated NFAT signaling synergizes with STAT1 to control T-bet expression and T_H1 differentiation

Feske and colleagues show how STIM- and ORAI-dependent calcium activation of NFAT plus IFN–STAT1 signaling activates T-bet expression independently of IL-12 stimulation. This NFAT–STAT1 activation pathway is required for T_H1 cell differentiation and protection against viral infections when IL-12 is missing.

Li Zhong
Yin-Hu Wang
Stefan Feske
Research21 Feb 2025
Nature Immunology

Volume: 26, P: 484-496
The overwintering situation and influencing factors of Fulmekiola serrata in Yunnan sugarcane planting areas of China

Jiong Yin
Ya-Lian Gao
You-Qing Chen
ResearchOpen Access25 Apr 2025
Scientific Reports

Volume: 15, P: 1-8
Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4⁺ T cell fate

It is debated how follicular helper T (Tfh) cells versus central memory CD4⁺ T cells arise from similar precursors, and little is known about the regulation of germinal-centre (GC)-Tfh cell differentiation. Here, authors establish markers in the early precursor stage that distinguish between the GC-Tfh and memory T cell fates and identify an important mechanism that regulates the competitive fitness of the GC-Tfh cells.

Fangming Zhu
Ryan J. McMonigle
Hui Hu
ResearchOpen Access17 Jun 2023
Nature Communications

Volume: 14, P: 1-15
The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling

Concepcion et al. show that the volume-regulated anion channel LRRC8C mediates the transport of cGAMP in T cells, resulting in a noncanonical STING–p53-dependent suppression of Ca²⁺ influx, T cell proliferation and cytokine production.

Axel R. Concepcion
Larry E. Wagner II
Stefan Feske
Research01 Feb 2022
Nature Immunology

Volume: 23, P: 287-302
Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels

Regulatory T (Treg) cells are important for maintaining immune homeostasis. Here the authors show that STIM1 and STIM2, which activate the Ca²⁺ channel ORAI1, are essential for the differentiation of peripheral Treg cells into tissue-resident and follicular Treg cells and their ability to limit autoimmunity in mice.

Martin Vaeth
Yin-Hu Wang
Stefan Feske
ResearchOpen Access12 Mar 2019
Nature Communications

Volume: 10, P: 1-16
Biofouling characteristics of reverse osmosis membranes by disinfection-residual-bacteria post seven water disinfection techniques

Hao-Bin Wang
Yin-Hu Wu
Hong-Ying Hu
ResearchOpen Access21 Mar 2023
npj Clean Water

Volume: 6, P: 1-8
Liver-resident NK cells suppress autoimmune cholangitis and limit the proliferation of CD4⁺ T cells

Zhi-Bin Zhao
Fang-Ting Lu
Zhe-Xiong Lian
Research15 Mar 2019
Cellular & Molecular Immunology

Volume: 17, P: 178-189
Block of both TGF-β and IL-2 signaling impedes Neurophilin-1⁺ regulatory T cell and follicular regulatory T cell development

Liang Li
Shu-Han Yang
Zhe-Xiong Lian
ResearchOpen Access27 Oct 2016
Cell Death & Disease

Volume: 7, P: e2439

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STIM1-mediated NFAT signaling synergizes with STAT1 to control T-bet expression and T_H1 differentiation

The overwintering situation and influencing factors of Fulmekiola serrata in Yunnan sugarcane planting areas of China

Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4⁺ T cell fate

The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling

Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels

Biofouling characteristics of reverse osmosis membranes by disinfection-residual-bacteria post seven water disinfection techniques

Liver-resident NK cells suppress autoimmune cholangitis and limit the proliferation of CD4⁺ T cells

Block of both TGF-β and IL-2 signaling impedes Neurophilin-1⁺ regulatory T cell and follicular regulatory T cell development

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