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Showing 1–4 of 4 results
Advanced filters: Author: Ying Z. Pigli Clear advanced filters

  • A screen utilizing an environmental DNA library in Escherichia coli is used to identify Brig1, a previously unknown anti-phage defence system with homologues across distinct clades of bacteria.

    • Amer A. Hossain
    • Ying Z. Pigli
    • Luciano A. Marraffini
    ResearchOpen Access
    Nature
    Volume: 629, P: 410-416

  • One of the conserved proteins of the Staphylococcus aureus mobile genomic island responsible for methicillin resistance is an active MCM-like helicase, thus suggesting replication that would enhance the efficiency of horizontal gene transfer.

    • Ignacio Mir-Sanchis
    • Christina A Roman
    • Phoebe A Rice
    Research
    Nature Structural & Molecular Biology
    Volume: 23, P: 891-898

  • The structure of the bacteriophage transposase MuA bound to DNA sequences that mimic both the transposon ends and the target DNA ends is solved; the picture of this synaptic complex illustrates the intricacy of Mu transposition, and exposes the architectural diversity among DDE recombinases in complex with substrate DNAs.

    • Sherwin P. Montaño
    • Ying Z. Pigli
    • Phoebe A. Rice
    Research
    Nature
    Volume: 491, P: 413-417

  • Normally, expression of bacterial DNA damage repair genes is repressed by the binding of LexA protein to SOS ‘boxes’ in their operators. DNA damage activates the RecA protein, which promotes autocleavage of LexA such that its repression is relieved and repair proteins are expressed. These authors solve several structures of LexA dimer bound to SOS box DNA, and find that the orientation of the DNA-binding wings can account for the strict intersite spacing.

    • Adrianna P. P. Zhang
    • Ying Z. Pigli
    • Phoebe A. Rice
    Research
    Nature
    Volume: 466, P: 883-886