Delivering plasmid DNA to solid tumors is challenging since it demands more transport steps than other genetic materials. Here this group designs a hybrid lipoplex for co-delivering p53 plasmid along with MDM2 inhibitor sp141 to hepatocellular carcinoma and lung carcinoma for synergistic anti-tumor treatment.
- Xueyi Hu
- Yichun Wang
- Xintao Shuai
