Native enzymes using Lewis acid catalysis in intramolecular [4+2] cycloaddition remain unreported. Herein, the authors report the ferredoxins catalyzed [4+2] cycloaddition in polycyclic macrolactam verticilactam biosynthesis using a transition-metal center.
- Yu Zheng
- Katsuyuki Sakai
- Shunji Takahashi