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Showing 1–11 of 11 results
Advanced filters: Author: Yonatan Stelzer Clear advanced filters
  • Cis regulatory elements endow genomes with sequence-encoded logic to drive cellular differentiation. Here, the authors introduce a biophysically principled sequence model that characterises complex TF-DNA interactions with accuracy that rivals state-of-the-art blackbox sequence foundation models.

    • Akhiad Bercovich
    • Aviezer Lifshitz
    • Amos Tanay
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17
  • Yonatan Stelzer highlights a landmark work from the lab of Howard Cedar that addresses how genome-wide DNA methylation patterns are established and instructed by the DNA sequence.

    • Yonatan Stelzer
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 24, P: 164
  • The miR-372-3 cluster has a role in oncogenesis. In this study, by utilizing parthenogenetic induced pluripotent stem cells, that lack the paternal genome, Stelzer et al.report that these miR-372-3 are negatively regulated by a paternally imprinted antisense transcript and that loss of its expression promotes oncogenesis.

    • Yonatan Stelzer
    • Ido Sagi
    • Nissim Benvenisty
    Research
    Nature Communications
    Volume: 4, P: 1-9
  • Here the authors investigate whether for imprinted genes the parent-of-origin of the expressed allele or rather appropriate gene dosage is more important for normal development. Using the differentially methylated region of Dlk1-Dio3 gene involved in imprinting, they show that correct parent-of-origin imprinting pattern is secondary to balanced gene dosage.

    • Ariella Weinberg-Shukron
    • Raz Ben-Yair
    • Yonatan Stelzer
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12
  • Eviction of histones from nucleosomes and their exchange with newly synthesized or alternative variants is a central epigenetic determinant. Here the authors implement a molecular sensor that reports on steady-state exchange of histones in mESC and mice revealing dependency between deposition of histone variant H3.3 and exchange of H3.1 and H2B in both open and closed chromatin.

    • Marko Dunjić
    • Felix Jonas
    • Yonatan Stelzer
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19
  • Nissim Benvenisty and colleagues use induced pluripotent stem cells (iPSCs) derived from individuals with Prader-Willi syndrome (PWS) to model PWS in vitro. By comparison to parthenogenetic human iPSCs, they find that the PWS-associated noncoding RNA IPW regulates maternally expressed genes at the DLK1-DIO3 imprinted region through its effect on H3K9me3 histone marks in that region.

    • Yonatan Stelzer
    • Ido Sagi
    • Nissim Benvenisty
    Research
    Nature Genetics
    Volume: 46, P: 551-557
  • It has long been known that in mammals maternally and paternally inherited genes can be differentially expressed. By generating human parthenogenetic induced pluripotent stem cell lines, the expression of parentally inherited genes is now examined genome wide, uncovering novel imprinted non-coding RNAs and demonstrating the consequences of parthenogenesis on human development.

    • Yonatan Stelzer
    • Ofra Yanuka
    • Nissim Benvenisty
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 735-741