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Showing 1–11 of 11 results

Advanced filters: Author: Yong-Hee Cho Clear advanced filters

5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation

The relative enrichment of cancer stem cells after treatment results in tumour recurrence. Here, the authors show a mechanism where p53 induces WNT3, which increases the number of colorectal cancer stem cells following treatment of 5-fluorouracil.

Yong-Hee Cho
Eun Ji Ro
Kang-Yell Choi
ResearchOpen Access21 Oct 2020
Nature Communications

Volume: 11, P: 1-13
Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation

A small-molecule compound binds to the RGS domain of axin, promotes the degradation of β-catenin and Ras through the GSK3β-mediated destruction complex, and reduces the growth of KRAS and APC mutant colorectal cancer cell lines.

Pu-Hyeon Cha
Yong-Hee Cho
Kang-Yell Choi
Research13 Jun 2016
Nature Chemical Biology

Volume: 12, P: 593-600
Metallic conduction induced by direct anion site doping in layered SnSe₂

Sang Il Kim
Sungwoo Hwang
Yoonchul Sohn
ResearchOpen Access21 Jan 2016
Scientific Reports

Volume: 6, P: 1-7
Human CD64-targeted non-viral siRNA delivery system for blood monocyte gene modulation

Seok-Beom Yong
Hyung Jin Kim
Yong-Hee Kim
ResearchOpen Access07 Feb 2017
Scientific Reports

Volume: 7, P: 1-12
A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer

Jieun Park
Yong-Hee Cho
Kang-Yell Choi
ResearchOpen Access24 Jan 2019
Scientific Reports

Volume: 9, P: 1-11
A small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab

Sang-Kyu Lee
Yong-Hee Cho
Kang-Yell Choi
ResearchOpen Access20 Nov 2018
Experimental & Molecular Medicine

Volume: 50, P: 1-12
A Phytochemical Approach to Promotion of Self-renewal in Murine Spermatogonial Stem Cell by Using Sedum Sarmentosum Extract

Sang-Eun Jung
Yong-Hee Kim
Buom-Yong Ryu
ResearchOpen Access12 Sept 2017
Scientific Reports

Volume: 7, P: 1-11
Neural stem cells secrete factors facilitating brain regeneration upon constitutive Raf-Erk activation

Yong-Hee Rhee
Sang-Hoon Yi
Sang-Hun Lee
ResearchOpen Access24 Aug 2016
Scientific Reports

Volume: 6, P: 1-16
Destabilization of β-catenin and RAS by targeting the Wnt/β-catenin pathway as a potential treatment for triple-negative breast cancer

Won-Ji Ryu
Jeong Dong Lee
Kang-Yell Choi
ResearchOpen Access26 May 2020
Experimental & Molecular Medicine

Volume: 52, P: 832-842
Identification of Ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of β-catenin signaling

Wookjin Shin
Sang-Kyu Lee
Kang-Yell Choi
ResearchOpen Access06 Jun 2018
Experimental & Molecular Medicine

Volume: 50, P: 1-10
CD4⁺VEGFR1^HIGH T cell as a novel Treg subset regulates inflammatory bowel disease in lymphopenic mice

Jin-Young Shin
IL-Hee Yoon
Chung-Gyu Park
Research27 Jul 2015
Cellular & Molecular Immunology

Volume: 12, P: 592-603

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5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation

Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation

Metallic conduction induced by direct anion site doping in layered SnSe₂

Human CD64-targeted non-viral siRNA delivery system for blood monocyte gene modulation

A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer

A small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab

A Phytochemical Approach to Promotion of Self-renewal in Murine Spermatogonial Stem Cell by Using Sedum Sarmentosum Extract

Neural stem cells secrete factors facilitating brain regeneration upon constitutive Raf-Erk activation

Destabilization of β-catenin and RAS by targeting the Wnt/β-catenin pathway as a potential treatment for triple-negative breast cancer

Identification of Ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of β-catenin signaling

CD4⁺VEGFR1^HIGH T cell as a novel Treg subset regulates inflammatory bowel disease in lymphopenic mice

Search

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