Type I interferon-dependent immunity is crucial for antiviral defense but must be tightly regulated to prevent tissue damage. Here, the authors present RNF167 as a negative regulator of RLR-triggered IFN activation, mediating K6- and K11-linked ubiquitination of RIG-I/MDA5 to promote proteasomal and autophagic degradation.
- Miao He
- Zixiao Yang
- Panpan Hou
