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Showing 1–5 of 5 results
Advanced filters: Author: Yongjun Sui Clear advanced filters

  • The V1-V2 loops of the HIV envelope protein play an important role in HIV vaccine development. Here, Rahman et al. demonstrate in macaques that the efficacy of V1-deleted envelope vaccines, abrogated by oral delivery of control nanoparticles, is rescued by nanoparticles carrying V2 scaffold peptide strengthening the mucosal V2-specific response.

    • Mohammad Arif Rahman
    • Massimiliano Bissa
    • Jay A. Berzofsky
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Effective regulation over the motion of self-propelled micro- and nanomotors is a challenging proposition. Now, self-assembled stomatocyte nanomotors with thermoresponsive polymer brushes have been designed that sense changes in local temperature and regulate the accessibility of the hydrogen peroxide fuel — thereby adjusting the speed and behaviour of nanomotor itself.

    • Yingfeng Tu
    • Fei Peng
    • Daniela A. Wilson
    Research
    Nature Chemistry
    Volume: 9, P: 480-486

  • Priming of naïve T cells is thought to occur in tissue-draining lymph nodes. Here Wang et al. show that vaginal mucosa, despite lacking structured lymphoid organs, can support priming of naïve CD8 T-cell responses and activation of memory CD8 T cells.

    • Yichuan Wang
    • Yongjun Sui
    • Jay A. Berzofsky
    Research
    Nature Communications
    Volume: 6, P: 1-13

  • The mucosa of the large intestine mucosa is an effective vaccination site for induction of protective mucosal immunity against rectal or vaginal viral infection but clinically is impractical. Here Qing Zhu et al. have developed an oral delivery system that encapsulates vaccine into pH-dependent poly(DL-lactic-co-glycolic acid) (PLGA) nanoparticles coated with Eudragit to protect against the low pH and enzymatic destruction of the stomach. This approach was shown to selectively target the large intestine in mice and induce antigen-specific T and B cell responses similar to that observed with intracolorectal vaccination.

    • Qing Zhu
    • James Talton
    • Jay A Berzofsky
    Research
    Nature Medicine
    Volume: 18, P: 1291-1296