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Showing 1–4 of 4 results
Advanced filters: Author: Yonglu Che Clear advanced filters

  • ESCAPE-seq (enhanced single-chain antigen presentation sequencing) is a massively parallel platform for screening of class I HLA–peptide combinations for antigen presentation. The authors assess more than 75,000 peptide–HLA combinations, revealing presented epitopes from oncogenic driver mutations and fusions across diverse HLA-A, HLA-B and HLA-C alleles.

    • Quanming Shi
    • Elana P. Simon
    • Howard Y. Chang
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 2062-2073

  • Small nucleolar RNAs, SNORD50A/B are frequently deleted in cancers and can inhibit KRAS but by unclear means. Here, the authors show that KRAS trafficking and enrichment on the plasma membrane is mediated by SNARE vesicle transport proteins and that SNORD50A/B compete with these proteins to antagonise these effects.

    • Yonglu Che
    • Zurab Siprashvili
    • Paul A. Khavari
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Paul Khavari and colleagues analyze tumor genomes to identify snoRNAs showing frequent copy number loss of adjacently encoded snoRNAs SNORD50A and SNORD50B. These snoRNAs directly bound K-Ras and their loss leads to increased activity of both wild-type and oncogenic K-Ras and is associated with reduced survival.

    • Zurab Siprashvili
    • Dan E Webster
    • Paul A Khavari
    Research
    Nature Genetics
    Volume: 48, P: 53-58