Nature Search

Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases

The development of brain metastases is a lethal yet poorly understood event in the evolution of many cancers. Here, the authors perform whole-genome and whole-exome sequencing on matched normal, primary and metastatic tissue samples to explore the genomic features of brain metastases in colorectal cancer.

Jing Sun
Cheng Wang
Yanhong Gu
ResearchOpen Access18 Jul 2019
Nature Communications

Volume: 10, P: 1-9
Structure of the origin recognition complex bound to DNA replication origin

The cryo-EM structure of the yeast origin recognition complex (ORC) bound to a 72-base-pair origin DNA sequence provides insights into the basis of the origin selection mechanism.

Ningning Li
Wai Hei Lam
Bik-Kwoon Tye
Research04 Jul 2018
Nature

Volume: 559, P: 217-222
Benmelstobart, anlotinib and chemotherapy in extensive-stage small-cell lung cancer: a randomized phase 3 trial

In this triple-arm, placebo-controlled phase 3 trial, first-line treatment of patients with extensive-stage small-cell lung cancer with the anti-PD-L1 benmelstobart, tyrosine kinase inhibitor anlotinib and chemotherapy (CT) showed improved survival outcomes compared with anlotinib and CT or CT alone.

Ying Cheng
Jianhua Chen
Runxiang Yang
ResearchOpen Access11 Jul 2024
Nature Medicine

Volume: 30, P: 2967-2976
Fruquintinib plus paclitaxel versus placebo plus paclitaxel for gastric or gastroesophageal junction adenocarcinoma: the randomized phase 3 FRUTIGA trial

In a randomized, double-blind, placebo-controlled phase 3 trial, the anti-vascular endothelial growth factor receptor small-molecule inhibitor fruquintinib plus chemotherapy significantly extended progression-free survival, but not overall survival, as second-line therapy in patients with advanced gastric or gastroesophageal junction cancers.

Feng Wang
Lin Shen
Rui-Hua Xu
Research01 Jun 2024
Nature Medicine

Volume: 30, P: 2189-2198
One-step synthesis of Nickle Iron-layered double hydroxide/reduced graphene oxide/carbon nanofibres composite as electrode materials for asymmetric supercapacitor

Feifei Wang
Ting Wang
Hongjuan Li
ResearchOpen Access11 Jun 2018
Scientific Reports

Volume: 8, P: 1-10
Genome-wide Association Study on Platinum-induced Hepatotoxicity in Non-Small Cell Lung Cancer Patients

Songyu Cao
Cheng Wang
Hongbing Shen
ResearchOpen Access23 Jun 2015
Scientific Reports

Volume: 5, P: 1-8
Weathering aging resistance in seasonal frozen regions: A comparative study of SBS- and SBR-modified asphalt binders through rheological and morphological characterization

Feng Wang
Rui Ma
Peifeng Cheng
ResearchOpen Access20 Apr 2025
Scientific Reports

Volume: 15, P: 1-18
Cellular processes involved in lung cancer cells exposed to direct current electric field

Huijuan Li
Shibin Liu
Yulong Sun
ResearchOpen Access24 Mar 2020
Scientific Reports

Volume: 10, P: 1-21
Toripalimab plus chemotherapy for first line treatment of advanced non-small cell lung cancer (CHOICE-01): final OS and biomarker exploration of a randomized, double-blind, phase 3 trial

Jia Zhong
Kailun Fei
Jie Wang
ResearchOpen Access24 Dec 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-9
Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population

Hongbing Shen and colleagues identify three new susceptibility loci for lung cancer in the Chinese population. Their follow-up analyses suggest that two of these loci interact multiplicatively with smoking dose to influence lung cancer risk.

Jing Dong
Zhibin Hu
Hongbing Shen
Research15 Jul 2012
Nature Genetics

Volume: 44, P: 895-899
Metabolic defects in splenic B cell compartments from patients with liver cirrhosis

Man Huang
Xiaoju Liu
Zheng Zhang
ResearchOpen Access24 Oct 2020
Cell Death & Disease

Volume: 11, P: 1-14
Diagnostic value of a plasma microRNA signature in gastric cancer: a microRNA expression analysis

Xin Zhou
Wei Zhu
Ping Liu
ResearchOpen Access10 Jun 2015
Scientific Reports

Volume: 5, P: 1-13
Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-β-dependent emperipolesis in HBV cirrhotic patients

Jijing Shi
Juanjuan Zhao
Zheng Zhang
ResearchOpen Access14 Mar 2017
Scientific Reports

Volume: 7, P: 1-14

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