BMP signalling is required for the emergence of haematopoietic stem cells (HSCs) from the zebrafish dorsal aorta. Here the authors show that FGF signalling negatively regulates HSC emergence by downregulating BMP activity in the zebrafish subaortic mesenchyme and upregulating the expression of BMP antagonists in the somite.
- Claire Pouget
- Tessa Peterkin
- Roger Patient
