Nature Search

Genetic insights into resting heart rate and its role in cardiovascular disease

The genetics and clinical consequences of resting heart rate (RHR) remain incompletely understood. Here, the authors discover new genetic variants associated with RHR and find that higher genetically predicted RHR decreases risk of atrial fibrillation and ischemic stroke.

Yordi J. van de Vegte
Ruben N. Eppinga
Pim van der Harst
ResearchOpen Access02 Aug 2023
Nature Communications

Volume: 14, P: 1-21
Genome-wide association studies and Mendelian randomization analyses for leisure sedentary behaviours

Epidemiological studies have shown an association between sedentary behaviours and cardiovascular disease risk. Here, van de Vegte et al. perform GWAS for self-reported sedentary behaviours (TV watching, computer use, driving) and Mendelian randomization analyses to explore potential causal relationships with coronary artery disease.

Yordi J. van de Vegte
M. Abdullah Said
Niek Verweij
ResearchOpen Access21 Apr 2020
Nature Communications

Volume: 11, P: 1-10
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

On the electrocardiogram, the PR interval reflects conduction from the atria to ventricles and also serves as risk indicator of cardiovascular morbidity and mortality. Here, the authors perform genome-wide meta-analyses for PR interval in multiple ancestries and identify 141 previously unreported genetic loci.

Ioanna Ntalla
Lu-Chen Weng
Patricia B. Munroe
ResearchOpen Access21 May 2020
Nature Communications

Volume: 11, P: 1-12
Atrial fibrillation and left atrial size and function: a Mendelian randomization study

Yordi J. van de Vegte
Joylene E. Siland
Pim van der Harst
ResearchOpen Access19 Apr 2021
Scientific Reports

Volume: 11, P: 1-9
Genetic study links components of the autonomous nervous system to heart-rate profile during exercise

Response of the heart rate (HR) to exercise is associated with cardiac fitness and risk of cardiac death. Here, in a genome-wide association study, Verweij et al. identify 23 loci for HR increase during exercise or HR recovery, and highlight pleiotropy with blood pressure by polygenic risk score analysis.

Niek Verweij
Yordi J. van de Vegte
Pim van der Harst
ResearchOpen Access01 Mar 2018
Nature Communications

Volume: 9, P: 1-9
Novel loci and biomedical consequences of iron homoeostasis variation

The largest meta-analysis of GWASs of hepcidin and sTfR identified 43 genomic loci, of which 15 new. Mendelian randomisation revealed associations of systemic iron status and iron-related loci with selected health outcomes across multiple domains.

Elias Allara
Steven Bell
Emanuele Di Angelantonio
ResearchOpen Access06 Dec 2024
Communications Biology

Volume: 7, P: 1-17
Fetuin-A and its genetic association with cardiometabolic disease

Lawien Al Ali
Yordi J. van de Vegte
Pim van der Harst
ResearchOpen Access06 Dec 2023
Scientific Reports

Volume: 13, P: 1-11
The Groningen electrocardiographic criteria for left ventricular hypertrophy: a sex-specific analysis

M. Yldau van der Ende
Tom Hendriks
Pim van der Harst
ResearchOpen Access23 Mar 2021
Scientific Reports

Volume: 11, P: 1-9
Human genetic determinants of the gut microbiome and their associations with health and disease: a phenome-wide association study

Hilde E. Groot
Yordi J. van de Vegte
Pim van der Harst
ResearchOpen Access08 Sept 2020
Scientific Reports

Volume: 10, P: 1-11

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