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Showing 1–6 of 6 results
Advanced filters: Author: York Posor Clear advanced filters

  • The spatiotemporal regulation of membrane scaffolds recruitment and coupling between membrane deformation and fission in endocytosis are unclear. Here the authors show that lipid conversion at endocytic pits recruits SNX9, which couples local membrane constriction to fission in endocytosis.

    • Johannes Schöneberg
    • Martin Lehmann
    • Frank Noé
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-17

  • Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that generate 3-phosphoinositides, which govern cellular signal transduction and membrane trafficking. The PI3K family comprises three classes of enzymes, which include several isoforms and complexes; the myriad of cellular functions and means of regulation of these enzymes are now coming into focus.

    • Benoit Bilanges
    • York Posor
    • Bart Vanhaesebroeck
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 20, P: 515-534

  • The crystal structure of the large GTPase dynamin tetramer is presented, suggesting a mechanism by which oligomerization of dynamin is regulated, and revealing how mutations that interfere with tetramer formation and autoinhibition are of relevance to understanding the congenital muscle disorders Charcot–Marie–Tooth neuropathy and centronuclear myopathy.

    • Thomas F. Reubold
    • Katja Faelber
    • Susanne Eschenburg
    Research
    Nature
    Volume: 525, P: 404-408

  • Phosphoinositides are important regulators of intracellular membrane traffic, and although the role of PI(4,5)P2 has been well characterised, the function of PI(3,4)P2 remains unclear; here the formation of PI(3,4)P2 by the class II phosphatidylinositol-3-kinase C2α enzyme is shown to control clathrin-mediated endocytosis.

    • York Posor
    • Marielle Eichhorn-Gruenig
    • Volker Haucke
    Research
    Nature
    Volume: 499, P: 233-237

  • Phosphoinositides are signalling, membrane lipids derived from phosphatidylinositol, whose intracellular distribution and interconversion via phosphoinositide kinases and phosphatases is tightly coupled to membrane dynamics. Accordingly, phosphoinositides are now recognized as key regulators of endocytic and exocytic traffic, the autolysosomal system, and membrane contact site organization and function.

    • York Posor
    • Wonyul Jang
    • Volker Haucke
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 23, P: 797-816