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Showing 1–9 of 9 results
Advanced filters: Author: Yosef Buganim Clear advanced filters

  • Here they perform a systematic dissection of OCT4 and reveal how intrinsically disordered regions can be used to serve specific functions during reprogramming and embryonic development. This can be exploited to engineer more efficient and specific reprogramming factors.

    • Burak Ozkan
    • Mitzy Rios de Anda
    • Abdenour Soufi
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-26

  • Ectopic transcription factor expression can reprogram mouse fibroblasts to pluripotent or trophoblast stem cells. Here the authors apply multi-omics analyses to the induction of pluripotency and trophoblast stem cell state from fibroblasts, comparing these with the changes in transcriptome of early embryonic cells.

    • Mohammad Jaber
    • Ahmed Radwan
    • Yosef Buganim
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21

  • Our understanding of the molecular steps that occur during reprogramming somatic cells to induced pluripotent stem cells has recently been improved through analyses of cell populations and single cells. Here the authors consider the phases of reprogramming, models for describing the process and the roles of reprogramming factors.

    • Yosef Buganim
    • Dina A. Faddah
    • Rudolf Jaenisch
    Reviews
    Nature Reviews Genetics
    Volume: 14, P: 427-439

  • Asynchronous replication-timing patterns undergo programmed switching between maternal and paternal alleles in embryonic and adult stem cells.

    • Hagit Masika
    • Marganit Farago
    • Howard Cedar
    Research
    Nature Structural & Molecular Biology
    Volume: 24, P: 1132-1138

  • Totipotency is the ability of a single cell to form an entire embryo, including extraembryonic tissues, an ability we have yet to recapitalize, in vitro. In a recent paper published in Science, Choi et al. showed that pluripotent stem cells lacking microRNA miR-34a, have an expanded cell fate potential allowing differentiation into not only embryonic but also extraembryonic lineages.

    • Noam Maoz
    • Yosef Buganim
    Research Highlights
    Cell Research
    Volume: 27, P: 600-601