Dysregulated hepatic glucose production (HGP) is a key feature of type 2 diabetes (T2D). Masato Kasuga and his colleagues now show that under physiological conditions, the expression and activity of the protein CITED2 in the liver is altered in response to hormonal cues that regulate HGP. They also show in a mouse model of T2D that hepatic CITED2 expression is elevated and that its genetic knockdown reduces serum glucose concentrations, suggesting this protein as a possible therapeutic target in the clinic.
- Mashito Sakai
- Michihiro Matsumoto
- Masato Kasuga