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Showing 1–8 of 8 results
Advanced filters: Author: Yoshiko Nakada-Nakura Clear advanced filters

  • Determination of the crystal structure of the human A2A adenosine receptor in complex with an inverse-agonist antibody shows that the allosteric site of the receptor inhibits agonist binding and that the antibody locks the receptor in an inactive conformation.

    • Tomoya Hino
    • Takatoshi Arakawa
    • Takeshi Murata
    Research
    Nature
    Volume: 482, P: 237-240

  • Tetraspanins play critical roles in various physiological processes, ranging from cell adhesion to virus infection. Here authors report the crystal structure of CD9 and the cryo-electron microscopic structure of CD9 in complex with its single membrane-spanning partner protein, EWI-2.

    • Rie Umeda
    • Yuhkoh Satouh
    • Osamu Nureki
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • This study has determined the X-ray crystal structures of GLUT5 from Rattus norvegicus in an open, outward-facing conformation and GLUT5 from Bos taurus in an open, inward-facing conformation; comparison of these structures with previously published structures of the related Escherichia coli d-xylose:H+ symporter XylE suggests that transport in GLUT5 is controlled by both a global ‘rocker-switch’-type motion and a local ‘gated-pore’-type transport mechanism.

    • Norimichi Nomura
    • Grégory Verdon
    • David Drew
    Research
    Nature
    Volume: 526, P: 397-401

  • The multidrug resistance transporter mediated efflux of antibiotics from the bacterial cytoplasm represents a major challenge to medicine. Here authors solve the X-ray crystallographic structure of the drug/H+ antiporter MdfA from Escherichia coli and shed light on the conformational switching mechanism.

    • Kumar Nagarathinam
    • Yoshiko Nakada-Nakura
    • Mikio Tanabe
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9

  • The crystal structure of the bacterial protein YidC is reported, together with a structure-based functional analysis, providing insight into the role of YidC in inserting single-spanning membrane proteins into the membrane.

    • Kaoru Kumazaki
    • Shinobu Chiba
    • Osamu Nureki
    Research
    Nature
    Volume: 509, P: 516-520